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CaMKIId Splice variants in the healthy and diseased heart
(Frontiers Media, 2021)
RNA splicing has been recognized in recent years as a pivotal player in heart
development and disease. The Ca2C/calmodulin dependent protein kinase II delta
(CaMKIId) is a multifunctional Ser/Thr kinase family and generates ...
Differential expression of new LTA splice variants upon lymphocyte activation
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Lymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses. Many TNF superfamily members have functionally ...
The connection between splicing and cancer
(Company Of Biologists, 2006)
Alternative splicing is a crucial mechanism for generating protein diversity. Different splice variants of a given protein can display different and even antagonistic biological functions. Therefore, appropriate control ...
A new portal for the analysis of human splicing variants
(LANDES BIOSCIENCEAUSTIN, 2012)
Understanding alternative splicing is crucial to elucidate the mechanisms behind several biological phenomena, including diseases. The huge amount of expressed sequences available nowadays represents an opportunity and a ...
Differential expression of new LTA splice variants upon lymphocyte activation
(Elsevier B.V., 2008-01-01)
Lymphotoxin alpha (LTA) is a member of the TNF cytokine superfamily, produced principally by lymphocytes. It plays an important role in immune and inflammatory responses. Many TNF superfamily members have functionally ...
Venomics of the Australian eastern brown snake (Pseudonaja textilis): detection of new venom proteins and splicing variants
(Elsevier B. V., 2015)
The eastern brown snake is the predominant cause of snakebites in mainland Australia. Its venom induces defibrination coagulopathy, renal failure and microangiopathic hemolytic anemia. Cardiovascular collapse has been ...
MLH1 intronic variants mapping to + 5 position of splice donor sites lead to deleterious effects on RNA splicing
(Springer, 2020-10)
Germline pathogenic variants in the DNA mismatch repair genes (MMR): MLH1, MSH2, MSH6, and PMS2, are causative of Lynch syndrome (LS). However, many of the variants mapping outside the invariant splice site positions (IVS ...
Heteroduplex formation and S1 digestion for mapping alternative splicing sites
(FUNPEC-EDITORA, 2008)
The identification of alternatively spliced transcripts has contributed to a better comprehension of developmental mechanisms, tissue-specific physiological processes and human diseases. Polymerase chain reaction amplification ...